Countries

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Participating Countries in Patient Enrolment

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EAST-STROKE is a collaborative effort and consists of several trials jointly investigating a shared research question. At the heart of this initiative is EAST-STROKE Europe, which will serve as the central and coordinating hub for a network of interconnected trials. These trials will also be conducted in Australia and Canada, where funding has already been approved, as well as in additional countries that are currently at various stages of preparation. By fostering international collaboration, EAST-STROKE aims to generate robust, globally relevant insights that will advance stroke research and improve patient outcomes worldwide.

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Germany • Deutschland

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Über EAST-STROKE

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EAST-STROKE (Early treatment of Atrial fibrillation for Stroke prevention Trial in acute STROKE) ist eine internationale, von Forschern initiierte Studie, in der untersucht wird, ob eine frühzeitige rhythmuserhaltende Therapie im Vergleich zur Standardversorgung unerwünschte kardiovaskuläre Ereignisse bei Patient:innen mit akutem ischämischem Schlaganfall und Vorhofflimmern verhindert.

Patient:innen, die an einem akuten ischämischen Schlaganfall und Vorhofflimmern leiden, haben ein besonders hohes Risiko für wiederkehrende Schlaganfälle und andere schwerwiegende kardiovaskuläre Ereignisse. Ziel der Studie ist es, Evidenz für optimierte Behandlungsstrategien zu liefern, die die Lebensqualität der Patient:innen verbessern und zu einer nachhaltigeren Gesundheitsversorgung beitragen. EAST-STROKE wird in mehreren Ländern – darunter auch Deutschland – durchgeführt und soll die zukünftige klinische Praxis weltweit prägen.

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Nationale Koordinatoren – Universitätsklinikum Hamburg-Eppendorf

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Dr. Märit Jensen
Klinik für Neurologie
E-Mail

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Prof. Dr. Andreas Metzner
Klinik für Kardiologie
E-Mail

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Teilnehmende Kliniken

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Vivantes Klinikum Neukölln
Neurologie (Principal Investigator: Prof. Dr. Darius Nabavi)
Kardiologie (Co-PI: Prof. Dr. Hüeseyin Ince)

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Universitätsklinikum Heidelberg
Neurologie (Principal Investigator: Prof. Dr. Peter Ringleb)
Kardiologie

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Universitätsklinikum Leipzig
Neurologie (Principal Investigator: Prof. Dr. med. Dominik Michalski
Kardiologie

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UKSH Campus Lübeck
Neurologie (Principal Investigator: Prof. Dr. Georg Royl)
Kardiologie

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Städtisches Klinikum Lüneburg
Neurologie (Principal Investigator: Prof. Dr. Waltraud Pfeilschifter)
Kardiologie

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Universitätsklinikum Mannheim
Neurologie (Principal Investigator: Prof. Dr. Angelika Alonso)
Kardiologie

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Universitätsklinikum Ulm
Neurologie (Principal Investigator: Prof. Dr. Karl Georg Häusler)
Kardiologie

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Universitätsklinikum OWL | Evangelisches Klinikum Bethel gGmbH
Neurologie (Principal Investigator: Prof. Dr. W.-R. Schäbitz)
Kardiologie

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FEK – Friedrich-Ebert-Krankenhaus Neumünster GmbH
Neurologie (Principal Investigator: Prof. Dr. J. Bösel)
Kardiologie

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Universitätsklinikum Erlangen
Neurologie (Principal Investigator: PD Dr. Stefan Gerner)
Kardiologie

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Universitätsklinikum Essen
Neurologie (Principal Investigator: Univ.-Prof. Dr. Martin Köhrmann)
Kardiologie

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Charité – Universitätsmedizin Berlin
Neurologie (Principal Investigator: Prof. Dr. Jan Scheitz)
Kardiologie

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UKGM Gießen und Marburg – Standort Gießen
Neurologie (Principal Investigator: PD Dr. Martin Jünemann)
Kardiologie

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Universitätsmedizin Frankfurt
Neurologie (Principal Investigator: PD Dr. Jan-Hendrik Schäfer)
Kardiologie

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Universitätsklinikum Tübingen
Neurologie (Principal Investigator: Prof. Dr. Annerose Mengel)
Kardiologie

Patientenorganisationen

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Deutsche Schlaganfall-Hilfe

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Deutsche Herzstiftung

Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) – 535121142

Netherlands • Nederlands

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Over EAST-STROKE

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EAST-STROKE (Early treatment of Atrial fibrillation for Stroke prevention Trial in acute STROKE) is een internationale klinische studie waarin wordt onderzocht of vroege ritmecontrole-therapie als aanvulling op de gebruikelijke zorg bij patiënten met een acuut herseninfarct en atriumfibrilleren (AF) de kans op een nieuw herseninfarct of een andere hart- of vaataandoening vermindert, vergeleken met alleen de gebruikelijke zorg.

Patiënten met AF die recent een herseninfarct hebben doorgemaakt hebben een aanzienlijke kans op een nieuwe beroerte of een andere ernstige hart-of vaataandoening. Het onderzoek heeft als doel bewijs te leveren voor verbeterde behandelingsstrategieën die de levenskwaliteit van patiënten verbeteren en bijdragen aan een duurzamere gezondheidszorg. EAST-STROKE wordt uitgevoerd in meerdere landen, waaronder Nederland en heeft als streven de toekomstige klinische praktijk wereldwijd vorm te geven.

Onderzoekscoördinatoren in Nederland – Universitair Medisch Centrum Utrecht

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Prof. dr. H. Bart van der Worp
Neuroloog

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Dr. K. Peter Loh
Cardioloog

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Berber Zweedijk
Studiecoördinator Neurologie
e-mail

Deelnemende klinieken

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Binnenkort beschikbaar

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Patiëntenorganisaties

Hersenletsel

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Hartstichting

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Spain • España

Sobre EAST-STROKE

EAST-STROKE (Early treatment of Atrial fibrillation for Stroke prevention Trial in acute STROKE) es un ensayo internacional iniciado por investigadores para comprobar si el tratamiento precoz para el control del ritmo cardíaco previene los resultados cardiovasculares adversos en pacientes con ictus isquémico agudo y fibrilación auricular, en comparación con la atención habitual.

Los pacientes que sufren un accidente cerebrovascular isquémico agudo y fibrilación auricular corren un riesgo especialmente alto de sufrir accidentes cerebrovasculares recurrentes y otros eventos cardiovasculares graves. El ensayo tiene como objetivo generar pruebas que permitan mejorar las estrategias de tratamiento, lo que mejorará la calidad de vida de los pacientes y contribuirá a una asistencia sanitaria más sostenible. El ensayo EAST-STROKE, que se lleva a cabo en varios países, entre ellos España, pretende dar forma a la práctica clínica futura en todo el mundo.

Coordinadores nacionales – Vall d’Hebron Institut de Recerca

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Dr Carlos Molina Cateriano
Neurologist, Head of the Neurology Section
Stroke and Stroke Processes Unit University Hospital Vall D´Hebron

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Clínicas participantes

Próximamente

Organizaciones de pacientes

Próximamente

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Switzerland • Schweiz • Suisse • Svizzera

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Über EAST-STROKE

Patient:innen, die an einem akuten ischämischen Schlaganfall und Vorhofflimmern leiden, haben ein besonders hohes Risiko für wiederkehrende Schlaganfälle und andere schwerwiegende kardiovaskuläre Ereignisse. Ziel der Studie ist es, Evidenz für optimierte Behandlungsstrategien zu liefern, die die Lebensqualität der Patient:innen verbessern und zu einer nachhaltigeren Gesundheitsversorgung beitragen. EAST-STROKE wird in mehreren Ländern – darunter auch in der Schweiz – durchgeführt und soll die zukünftige klinische Praxis weltweit prägen.

À propos d’EAST-STROKE

EAST-STROKE (Early treatment of Atrial fibrillation for Stroke prevention Trial in acute STROKE) est un essai clinique international initié par les investigateurs eux-mêmes et cherchant à déterminer si un traitement précoce visant à contrôler le rythme cardiaque, comparé aux soins habituels, permet de prévenir les complications cardiovasculaires chez les patients victimes d’un AVC ischémique aigu et souffrant de fibrillation auriculaire.

Les patients souffrant d’un AVC ischémique aigu et de fibrillation auriculaire présentent un risque particulièrement élevé de récidive d’AVC et d’autres événements cardiovasculaires graves. L’essai vise à générer l’évidence nécessaire pour permettre d’améliorer les stratégies de traitement afin d’améliorer la qualité de vie des patients et de contribuer à des soins de santé plus durables. Mené dans plusieurs pays, dont la Suisse, EAST-STROKE cherche à façonner la pratique clinique future à l’échelle mondiale.

Su EAST-STROKE

EAST-STROKE (Early treatment of Atrial fibrillation for Stroke prevention Trial in acute STROKE) è uno studio internazionale avviato da ricercatori per verificare se la terapia precoce di controllo del ritmo cardiaco prevenga esiti cardiovascolari avversi nei pazienti con ictus ischemico acuto e fibrillazione atriale rispetto alle cure standard.

I pazienti affetti da ictus ischemico acuto e fibrillazione atriale sono particolarmente a rischio di ictus ricorrenti e altri gravi eventi cardiovascolari. Lo studio mira a fornire prove scientifiche a sostegno di strategie terapeutiche migliorate che aumentino la qualità della vita dei pazienti e contribuiscano a un’assistenza sanitaria più sostenibile. Condotto in diversi paesi, tra cui la Svizzera, EAST-STROKE mira a plasmare la futura pratica clinica a livello mondiale.

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Nationale Koordinatoren | Coordinateurs nationaux de l’essai | Coordinatori nazionali dello studio
Inselspital Universitätsspital Bern

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Prof. Urs Fischer
Universitätsklinik für Neurologie
email

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Prof. Tobias Reichlin
Universitätsklinik für Kardiologie
email

Patientenorganisationen | Organisations de patients | Organizzazioni di pazienti

Schweizerische Herzstiftung – Fondation Suisse de Cardiologie – Fondazione Svizzera di Cardiologia

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FRAGILE

Funded by the State Secretariat for Education, Research and Innovation (SERI)

Australia

About EAST-STROKE

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EAST-STROKE (Early treatment of Atrial fibrillation for Stroke prevention Trial in acute STROKE) is an international, investigator-initiated trial that examines whether early rhythm-control therapy, compared with standard care, prevents adverse cardiovascular events in patients with acute ischemic stroke and atrial fibrillation.

Patients with acute ischemic stroke and atrial fibrillation have a particularly high risk of recurrent strokes and other serious cardiovascular events. The aim of the study is to generate evidence for optimized treatment strategies that improve patients’ quality of life and contribute to a more sustainable healthcare system. EAST-STROKE is being conducted in several countries – including Australia – and aims to shape future clinical practice worldwide.

National Coordinators – Royal Melbourne Hospital

Prof Bruce Campbell

Prof Jon Kalman

Participating sites in Australia

Royal Melbourne Hospital, VIC
Austin Hospital, VIC
Alfred Hospital, VIC
Monash Medical Centre, VIC
Royal Adelaide Hospital, SA
Liverpool Hospital, NSW
Prince of Wales Hospital, NSW
Campbelltown Hospital, NSW
John Hunter Hospital, NSW
Princess Alexandra Hospital, NSW
Royal Brisbane and Women’s Hospital, QLD
Gold Coast University Hospital, QLD
Townsville University Hospital, QLD
Sir Charles Gardiner Hospital, WA
Fiona Stanley Hospital, WA
St Vincent’s Hospital Melbourne, VIC

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Patient organisations

Stroke Foundation

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Heart Foundation

Funded by the MRFF, Grant Number MRF2025554

Canada

About EAST-STROKE

Patients with acute ischemic stroke and atrial fibrillation have a particularly high risk of recurrent strokes and other serious cardiovascular events. The study aims to generate evidence for optimized treatment strategies that improve patients’ quality of life and contribute to a more sustainable healthcare system. EAST-STROKE is being conducted in several countries, including Canada, and aims to shape future clinical practice worldwide.

National Coordinators

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Dr. Luciano Sposato
Western University, London, Ontario
email

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Dr. Michael Hill
University of Calgary, Alberta
email

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Dr. Jason Andrade
University of British Columbia
email

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Participating sites in Canada

Coming soon

Patient organisations

Heart & Stroke Foundation of Canada

Funded by the Canadian Institutes of Health Research (CIHR)

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Japan

About EAST-STROKE

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In the context of Japan’s rapidly aging population, atrial fibrillation (AF) is a significant public health concern, particularly in relation to stroke. While oral anticoagulants have proven effective in mitigating the risk of ischemic stroke, a substantial number of stroke recurrences persist among AF patients with a history of ischemic stroke. Although early rhythm-control therapy is not yet widely adopted following stroke onset, it presents a promising supplementary option for secondary prevention due to its demonstrated efficacy in reducing strokes and other severe cardiovascular events.

At the National Cerebral and Cardiovascular Center in Japan, we collaborate closely with a multidisciplinary brain-heart team to address the burden of strokes and cardiovascular diseases. We firmly believe that our extensive nationwide network would be an ideal platform for conducting this trial.

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EAST-STROKE(Early treatment of Atrial fibrillation for Stroke prevention Trial in acute STROKE)は、急性期脳梗塞および心房細動を有する患者さんにおいて、通常治療に早期リズムコントロール療法を加える治療戦略が通常治療単独と比較して脳心血管系の有害イベントを予防できるかを検証する、国際研究者主導型臨床試験です。急性期脳梗塞と心房細動を合併した患者さんは、脳梗塞の再発やその他の重篤な脳心血管イベントのリスクが特に高い状態です。本試験は、患者さんの生活の質向上と、より持続可能な医療へ貢献できる、治療戦略の改善に関するエビデンスの創出を目指しています。ドイツ、日本を含む複数国で実施されるEAST-STROKEは、今後の世界の実地臨床のあり方を改善することを目指しています。

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National Coordinators – National Cerebral and Cardiovascular Center

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Dr. Masatoshi Koga
Department of Cerebrovascular Medicine
email

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Dr. Kengo Kusano
Department of Cardiovascular Medicine
email

Participating sites in Japan

近日公開

Patient organisations

Japan Stroke Association

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Japanese Circulation Association

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Funded by the Japan Agency for Medical Research and Development (AMED) – 26ek0210225h0001

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